DuPont™ AmberChrom™ XT30 Chromatography Resin
DuPont™ AmberChrom™ XT30 chromatography resin is a macroporous polymeric resin for preparative reverse phase high-performance liquid chromatography (HPLC), delivering high yields and purities. This resin is used in bioprocessing applications and is optimized for therapeutic oligonucleotide and peptide purifications. With its high mechanical robustness and chemical resistance, it is an excellent alternative to reverse phase silica. DuPont™ AmberChrom™ XT30 SL chromatography resin is designed as a viable option for purification processes that need balanced resolution and pressure-flow properties.
DuPont also offers DuPont™ AmberChrom™ XT30 SL chromatography resin, a slurried form of DuPont™ AmberChrom™ XT30 chromatography resin, eliminating the slurry preparation step in downstream processing for customers. With DuPont™ AmberChrom™ XT30 SL chromatography resin, customers do not have to hydrate the resin before use and can immediately begin with column packing.
Uses
- Capture, separation, and purification of peptides
- Purification of oligonucleotides from impurities (failure sequences, DMT-Off, oxidation products)
- Final polishing to remove trace impurities
Advantages
- Mechanical stability and chemical robustness to standard reverse-phase solvents and cleaning agents
- Stable within a very broad pH range (up to pH 14), and easily cleaned in place (CIP) with most organic solvents and dilute acids and bases
- Suitable for high-resolution, high-pressure chromatography