DuPont™ AmberChrom™ 50Wx2 200-400 H Fine Mesh Ion Exchange Resin

DuPont™ AmberChrom™ fine mesh cation exchange resins are microporous (gel) resins based on polystyrene crosslinked with divinylbenzene (DVB) and functionalized with sulfonic acid ligands. These ion exchange chromatography resins are used in the front-end of drug processes to help purify raw materials, adjust pH or desalt, remove surfactants from drug streams, and increase product purity and concentration in crude purifications. With its light crosslinking level, the AmberChrom™ 50Wx2 series provides the most open network of the DuPont™ AmberChrom™ fine mesh cation exchange products and is an excellent choice for applications that need to process drugs and raw materials up to ~ 2700 Dalton molecular weight. There are three products in this 50Wx2 series.

DuPont™ AmberChrom™ 50Wx2 200-400 H fine mesh resin has the smallest particle size of the 50Wx2 series. It is an ideal choice for processes that are willing to accept higher backpressure for faster kinetics. Screened with 200-400 mesh, approximate particle size range of 35-75 µm. See Product Data Sheet for details.

Product Data Sheet

FDA Letter

Uses

Purification of small molecule drugs (e.g., erythromycin)
Desalting and pH adjustment
Raw material purification
Surfactant removal
Crude purification and concentration of products
Solid phase catalysis

Advantages

Strong cation exchange resins based a microporous copolymer of styrene and divinylbenzene
Improved kinetics compared to traditional ion exchange resins
Compatible with a broad range of pH and buffer choices
Consistent performance across many cleaning cycles