DuPont™ AmberChrom™ 50Wx8 200-400 H Fine Mesh Ion Exchange Resin

DuPont™ AmberChrom™ fine mesh cation exchange resins are microporous (gel) resins based on polystyrene crosslinked with divinylbenzene (DVB) and functionalized with sulfonic acid ligands. These ion exchange chromatography resins are used in the front-end of drug processes to help purify raw materials, adjust pH or desalt, remove surfactants from drug streams, and increase product purity and concentration in crude purifications. With its high crosslinking level, the AmberChrom™ 50Wx8 series provides the tightest resin network of the DuPont™ AmberChrom™ fine mesh cation exchange products and is an ideal choice for applications that need to process drugs and raw materials smaller than ~1000 Dalton molecular weight with minimal swelling. There are three products in this 50Wx8 series.

DuPont™ AmberChrom™ 50Wx8 200-400 H fine mesh resin has the smallest particle size of the 50Wx8 series and is an excellent choice for processes that are willing to accept higher backpressure for faster kinetics. Screened with 200-400 mesh, approximate particle size range of 35-75 µm. See Product Data Sheet for details.

Product Data Sheet

FDA Letter

Uses

Purification of small molecule drugs (e.g., erythromycin)
Desalting and pH adjustment
Raw material purification
Surfactant removal
Crude purification and concentration of products
Solid phase catalysis

Advantages

Strong cation exchange resins based a microporous copolymer of styrene and divinylbenzene
Improved kinetics compared to traditional ion exchange resins
Compatible with a broad range of pH and buffer choices
Consistent performance across many cleaning cycles